Movement Disorders (revue)

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Abnormal Visual Activation in Parkinson's Disease Patients

Identifieur interne : 001F73 ( Main/Exploration ); précédent : 001F72; suivant : 001F74

Abnormal Visual Activation in Parkinson's Disease Patients

Auteurs : Ellison Fernando Cardoso [Brésil] ; Felipe Fregni [États-Unis] ; Fernanda Martins Maia [Brésil] ; Luciano M. Melo [Brésil] ; Joao R. Sato [Brésil] ; Antonio Cesario Jr Cruz [Brésil] ; Edno Tales Bianchi [Brésil] ; Danilo Botelho Fernandes [Brésil] ; Mário Luiz Ribeiro Monteiro [Brésil] ; Egberto Reis Barbosa [Brésil] ; Edson Jr Amaro [Brésil]

Source :

RBID : Pascal:10-0413279

Descripteurs français

English descriptors

Abstract

Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.


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Le document en format XML

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<title level="j" type="main">Movement disorders</title>
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<term>Maladie de Parkinson</term>
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<div type="abstract" xml:lang="en">Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.</div>
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<name sortKey="Cruz, Antonio Cesario Jr" sort="Cruz, Antonio Cesario Jr" uniqKey="Cruz A" first="Antonio Cesario Jr" last="Cruz">Antonio Cesario Jr Cruz</name>
<name sortKey="Maia, Fernanda Martins" sort="Maia, Fernanda Martins" uniqKey="Maia F" first="Fernanda Martins" last="Maia">Fernanda Martins Maia</name>
<name sortKey="Melo, Luciano M" sort="Melo, Luciano M" uniqKey="Melo L" first="Luciano M." last="Melo">Luciano M. Melo</name>
<name sortKey="Reis Barbosa, Egberto" sort="Reis Barbosa, Egberto" uniqKey="Reis Barbosa E" first="Egberto" last="Reis Barbosa">Egberto Reis Barbosa</name>
<name sortKey="Ribeiro Monteiro, Mario Luiz" sort="Ribeiro Monteiro, Mario Luiz" uniqKey="Ribeiro Monteiro M" first="Mário Luiz" last="Ribeiro Monteiro">Mário Luiz Ribeiro Monteiro</name>
<name sortKey="Sato, Joao R" sort="Sato, Joao R" uniqKey="Sato J" first="Joao R." last="Sato">Joao R. Sato</name>
<name sortKey="Sato, Joao R" sort="Sato, Joao R" uniqKey="Sato J" first="Joao R." last="Sato">Joao R. Sato</name>
</country>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Fregni, Felipe" sort="Fregni, Felipe" uniqKey="Fregni F" first="Felipe" last="Fregni">Felipe Fregni</name>
</region>
</country>
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